Choose one of the following short answer questions to answer…
Choose one of the following short answer questions to answer in the space below. Include the number of the question that you are answering to clearly identify your choice. 1. Explain the ABCDE rule for identifying potential melanomas. List and describe the significance of each component (A, B, C, D & E) in early detection of skin cancer. 2. Sickle cell anemia is an autosomal recessive disease that results in the production of abnormal hemoglobin (HbS). This unstable HbS molecule can result in episodes of “sickle cell crisis” under certain conditions. Describe the pathophysiological changes that occur during a sickle cell crisis. How do these changes contribute to the clinical symptoms experienced by affected individuals? (Include the following in your answer: What physiologic condition causes sickle cell crisis to develop? Name at least one example of a trigger for sickle cell crisis. What happens to erythrocytes during sickle cell crisis, and how does this affect the microcirculation? What does this alteration in circulation lead to?) 3. Discuss the phrase “shift-to-the left” as it relates to neutrophil count. What does a “shift to the left” in neutrophils indicate, and how is it detected? What underlying pathophysiologic condition that results in a “shift-to-the-left”? 4. Discuss the pathophysiology of disseminated intravascular coagulation (DIC). Include at least one example of an underlying condition that may lead to the development of DIC. Be sure to include an explanation of how the paradox of widespread clot formation and hemorrhage occur simultaneously in DIC.
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