Consider the neurotransmitters shown below. Notice similarities and differences, then answer the questions below *** a) The pharmacophore of these three compounds is best described as: [blank1] *** b) What is the significance of the “Iso” in the isoprenaline chemical name? [blank2] *** c) What is the significance of the “NOR” in the noradrenaline chemical name? [blank3] *** d) If Noradrenaline binds better to “alpha receptors” while isoprenaline binds better to “beta receptors” and Adrenaline binds equally well to both “alpha” and “beta receptors”….              Suggest a STRUCTURE BASED explanation for these differences in selectivity. [blank4]

The drugs Irinotecan, hydrocortisone, and haloperidol have very different pharmacophores. As such, they will likely exhibit ______ biological and/or pharmacological activity.

Consider the structure of Vitamin A shown here. Label the statements as either TRUE or FALSE…

Consider the panel of amines. Match the amine with its appropriate chemical classification / description:

A drug classified as a weak unionized base would form a salt with which of the following? (if more than one answer is correct, select all that apply)

Honor Code Statement: “The work on this exam is my own and I pledge to not use any outside resources, devices or people to help me.  I pledge that I will not cheat or assist anyone else in cheating”.  Proverbs 10:9 — Whoever walks in integrity walks securely, but whoever takes crooked paths will be found out. Prayer: Philippians 4:6–7 — Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.

Match the statements to the correct word or phrase that completes the statement:

Consider the panel of amines. For blank 1 – Select the amine group that is likely the STRONGEST hydrogen bond acceptor. [blank1] For blank 2 – Give a BRIEF explanation for your choice (hint: comparison to the others is helpful) [blank2]

“Duty”, “Harm”, “Breach”, and “Causation” are the four key elements of:

What three conditions must be present for a fire to start? I.   heat II.  oxygen III. combustible material (fuel) IV. low humidity