What does the term HLA-DQ designate?

A patient’s diagnosis is ataxia-telangiectasia. The physician wants to know if the patient has a mutation associated with increased risk for developing cancer. Which of the following genes should be examined for mutations in this patient?

Which of the following methods that can be used to determine HLA types is only a low-resolution method?

Which is a nucleic acid–based test?

Mutations in the VHL gene are associated with what condition?

Which of the following targets is tissue specific but not necessarily tumor specific?

In PCR-SSOP methods for HLA typing, the primers used to amplify the region are complementary to sequences present in which exon of the class II genes?

Five one- and two-base repeat loci were tested for instability, comparing cancer tissue to reference normal tissue from the same patient. Three of the five loci showed additional alleles in the cancer cells compared to the normal cells. How is this interpreted?

A PCR assay is performed on a patient with presumptive mantle cell lymphoma using primers against the immunoglobulin heavy chain gene and the cyclin D1 (CCND1) gene. Capillary gel electrophoresis was used for product detection, and the patient did not have a detectable PCR product. All controls were acceptable. Which of the following is the correct interpretation of this result?

Herceptin (trastuzumab) therapy works best on what tumors?