You have identified a mutant in which some newly divided cel…
You have identified a mutant in which some newly divided cells die shortly after cell division, while others survive but exhibit an extra copy of one or more chromosomes. Interestingly, when the cells are cultured under conditions that slow down their progression through the cell cycle, the defect is no longer observed, suggesting that the mitotic spindle and chromosome segregation machinery are functioning normally. Which cell cycle checkpoint might be defective in this mutant? Provide a detailed explanation of your reasoning. Describe in detail the normal functioning of this checkpoint, including its role in maintaining genomic stability.
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