The primary site of biotransformation of amide local anaesthetic take place in the:1.        Stomach2.        Kidney3.        Blood plasma4.        Lungs5.        Liver 

Describe the mechanism of action of amphotericin B.                                                        

An antagonist is a substance that:                                                                                               1.       Decreases the action of endogenous ligand2.       Produces no effect3.       Binds to identical receptor macromolecules as the agonist 4.       Increases the action of endogenous ligand5.       Has weak affinity for the target receptor 

The following opioid is classified as ultra-short acting:                                                    1.        Morphine2.        Pethidine3.        Tramadol4.        Fentanyl5.       Remifentanil 

The following drug is classified as a selective Cyclooxygenase (COX-2 inhibitor):     1.        Celecoxib2.        Tramadol3.        Morphine4.        Paracetamol5.       Diazepam 

The major routes of drug excretion include:                                                                         1.       Hepatic metabolism 2.       Pulmonary elimination3.       Urine excretion4.       Breastmilk ejection5.       Biliary elimination 

Match each of the following drugs with a corresponding description. Each answer may be used more than once or not at all.

The following statements is correct regarding tachyphylaxis:                                        1.       There is a decreased receptor-mediated response to a drug 2.       There is an increased risk of side effects occurring3.       Smaller doses cause an increased response to a drug4.       The rate of drug infusion equals the rate of excretion5.       The drug does not bind to receptors completely 

Which of the following are irreversible:                                                                                1.       Electrostatic forces2.       Hydrogen bonds3.       Van der Waals forces4.       Covalent bonds 5.       Metallic bond  

Terizidone is contraindicated in the following conditions:                                            1.        Epilepsy2.        Drug resistant Mycobacterium tuberculosis 3.        Pyridoxine therapy4.        Severe renal impairment5.        Alcohol abuse