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Frоm Wikipediа: Hemоphiliа figured prоminently in the history of Europeаn royalty in the 19th and 20th centuries. Prior to Queen Victoria, there were no documented cases in the history of the royal family. Queen Victoria of the United Kingdom, through two of her five daughters – Princess Alice and Princess Beatrice– passed the mutation to various royal houses across the continent, including the royal families of Spain, Germany, and Russia. Victoria's youngest son, Prince Leopold, Duke of Albany, also had the disease, though none of her three elder sons did. Tests on the remains of the Romanov imperial family show that the specific form of haemophilia passed down by Queen Victoria was probably the relatively rare haemophilia B. After Victoria, the presence of haemophilia B within the European royal families was well-known, with the condition once popularly known as "the royal disease". What genetic factors explain this high prevalence of this disorder? Prince Leopold, Duke of Albany (died as a consequence of hemophilia at age 31):