The abrupt discontinuation of an antagonist medication (such…
The abrupt discontinuation of an antagonist medication (such as a beta blocker) is often contraindicated because the constant use of an antagonist promotes the upregulation of receptors for the ligand that the drug is occupying receptor sites for. As a result, if you abruptly discontinue its use, there is a greater likelihood of the biologically active ligand binding to receptors causing a greater cellular response.
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